Endofluke

For the treatment of adult,immature and early immature stages of liver fluke susceptible to triclabendazole in cattle and sheep.
Benefits:
Triclabendazole-based fluke treatment
Kills early immature, immature, and adult liver fluke
Complete chronic and acute fluke control in both cattle and sheep
Low volume dose helps ensure accurate dosing of stock
Approved for use on dairy cattle
Withdrawal Periods:
Meat and Offal:
Cattle: 56 days
Sheep: 56 days
Dosage:
Endofluke 100 mg/ml is given as an oral drench and is suitable for most types of automatic drenching guns. The recommended dose rate is 12mg triclabendazole per kg body weight in cattle and 10mg triclabendazole per kg body weight in sheep.
To ensure administration of a correct dose, body weight should be determined as accurately as possible; accuracy of the dosing device should be checked. If animals are to be treated collectively rather than individually, they should be grouped according to their bodyweight and dosed accordingly, in order to avoid under- or overdosing.The timing for re-treatment should be based on epidemiological risk patterns and should be customised for each individual farm. To avoid the potential for the accumulation of residues following repeat administration of the product; animals should not be treated with a frequency of less than 10 weeks.
Practical Dosage Guide: CATTLE 6 ml per 50kg body weight
Animal Weight Dose of product
50kg 6ml
100kg 12ml
150kg 18ml
200kg 24ml
250kg 30ml
300kg 36ml
350kg 42ml
400kg 48ml
For each additional 50kg 6ml
Practical Dosage Guide: SHEEP 1 ml per 10kg body weight
Animal Weight Dose of product
10kg 1ml
20kg 2ml
30kg 3ml
40kg 4ml
50kg 5ml
60kg 6ml
For each additional 10kg 1ml
Withdrawal Period:
Cattle: Milk for human consumption may only be taken from 48 hours after calving.
Not intended for use within 45 days of calving. Should a cow calve earlier than 45 days after the last treatment, milk for human consumption may only be taken from 45
days + 48 hours (47 days) after the last treatment.
Sheep: Not authorised for use in ewes producing milk for human consumption, including during the dry period. Do not use within 1 year prior to the first lambing in ewes intended to produce milk for human consumption.
Special Warnings for Each Target Species:
Care should be taken to avoid the following practices, because they increase the risk of development of resistance and could ultimately result in ineffective therapy:
Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
Under-dosing, which may be due to underestimation of body weight, misadministration of the product or lack of calibration of the dosing device.
Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.
Resistance to triclabendazole has been reported in Fasciola hepatica in cattle and sheep.Therefore, the use of this product should be based on local (regional/farm) epidemiological information about susceptibility of the Fasciola hepatica and recommendations on how to limit further selection for resistance to anthelmintics.

Endofluke Data Sheet